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Researchers have discovered that not
ginger extract is extremely toxic to lung cancer cells,
and it’s metabolites (break-down products) are even more
toxic. 6-Gingerol, is a major anti-cancer compound of ginger,
and when it was metabolized into 6-gingerdiol inside the cells,
it then killed up to 76% of the lung cancer cells.
Ginger is looks pretty promising for activity against
breast cancer, prostate cancer, leukemia, pancreatic
cancer and colon cancer in previous studies.
A study out of India showed that people who
consume ginger daily had a 68% less risk of
developing lung cancer. Recent clinical trials
show Ginger also improves insulin sensitivity and lowers insulin levels in adults with diabetes, and also significantly improves memory and cognitive performance in middle-aged adults! Ginger tastes great in stir fries,
fish, curries, chutney, salad, baked in cookies or cake. Or simply steep the freshly chopped root in boiled water for a few minutes for a delicious tea (great sweetened with honey or stevia), and be sure to eat the slices too (which are rather spicy) for maximum benefit.
"Abstract
6-Gingerol, a major pungent component of ginger (Zingiber officinale Roscoe, Zingiberaceae), has been reported to have antitumor activities. However, the metabolic fate of 6-gingerol and the contribution of its metabolites to the observed activities are still unclear. In the present study, we investigated the biotransformation of 6-gingerol in different cancer cells and in mice, purified and identified the major metabolites from human lung cancer cells, and determined the effects of the major metabolites on the proliferation of human cancer cells. Our results show that 6-gingerol is extensively metabolized in H-1299 human lung cancer cells, CL-13 mouse lung cancer cells, HCT-116 and HT-29 human colon cancer cells, and in mice. The two major metabolites in H-1299 cells were purified and identified as (3R,5S)-6-gingerdiol (M1) and (3S,5S)-6-gingerdiol (M2) based on the analysis of their 1D and 2D NMR data. Both metabolites induced cytotoxicity in cancer cells after 24 h, with M1 having a comparable effect to 6-gingerol in H-1299 cells."
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